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Somatic hypermutation of immunoglobulin and non-immunoglobulin genes.

Somatic hypermutation (SHM) of immunoglobulin (Ig) genes is a highly specific mechanism restricted to B lymphocytes during only a few cell generations. Data presented here suggest that transcription of the target genes is required, but not sufficient for SHM. Presumably, cis-acting elements, such as...

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Bibliografiske detaljer
Main Authors: Storb, U, Shen, H M, Michael, N, Kim, N
Format: Artigo
Sprog:Inglês
Udgivet: 2001
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087686/
https://ncbi.nlm.nih.gov/pubmed/11205325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2000.0743
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