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Somatic hypermutation of immunoglobulin and non-immunoglobulin genes.
Somatic hypermutation (SHM) of immunoglobulin (Ig) genes is a highly specific mechanism restricted to B lymphocytes during only a few cell generations. Data presented here suggest that transcription of the target genes is required, but not sufficient for SHM. Presumably, cis-acting elements, such as...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2001
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1087686/ https://ncbi.nlm.nih.gov/pubmed/11205325 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2000.0743 |
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