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Brca1 in immunoglobulin gene conversion and somatic hypermutation
Defects in Brca1 confer susceptibility to breast cancer and genomic instability indicative of aberrant repair of DNA breaks. Brca1 was previously implicated in the homologous recombination pathway via effects on the assembly of recombinase Rad51. Activation-induced cytidine deaminase (AID) deaminate...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2007
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2267027/ https://ncbi.nlm.nih.gov/pubmed/18036997 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2007.10.002 |
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