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Control of gene conversion and somatic hypermutation by immunoglobulin promoter and enhancer sequences

It is thought that gene conversion (GCV) and somatic hypermutation (SHM) of immunoglobulin (Ig) genes occur in two steps: the generation of uracils in DNA by activation-induced cytidine deaminase, followed by their subsequent repair by various DNA repair pathways to generate sequence-diversified pro...

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Autori principali: Yang, Shu Yuan, Fugmann, Sebastian D., Schatz, David G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118177/
https://ncbi.nlm.nih.gov/pubmed/17178919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20061835
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