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Control of gene conversion and somatic hypermutation by immunoglobulin promoter and enhancer sequences

It is thought that gene conversion (GCV) and somatic hypermutation (SHM) of immunoglobulin (Ig) genes occur in two steps: the generation of uracils in DNA by activation-induced cytidine deaminase, followed by their subsequent repair by various DNA repair pathways to generate sequence-diversified pro...

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Detalhes bibliográficos
Main Authors: Yang, Shu Yuan, Fugmann, Sebastian D., Schatz, David G.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118177/
https://ncbi.nlm.nih.gov/pubmed/17178919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20061835
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