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DNA polymerases and somatic hypermutation of immunoglobulin genes
Somatic hypermutation of immunoglobulin variable genes, which increases antibody diversity, is initiated by the activation-induced cytosine deaminase (AID) protein. The current DNA-deamination model posits that AID deaminates cytosine to uracil in DNA, and that mutations are generated by DNA polymer...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1369213/ https://ncbi.nlm.nih.gov/pubmed/16319960 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400582 |
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