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DNA polymerases and somatic hypermutation of immunoglobulin genes

Somatic hypermutation of immunoglobulin variable genes, which increases antibody diversity, is initiated by the activation-induced cytosine deaminase (AID) protein. The current DNA-deamination model posits that AID deaminates cytosine to uracil in DNA, and that mutations are generated by DNA polymer...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Seki, Mineaki, Gearhart, Patricia J, Wood, Richard D
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2005
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1369213/
https://ncbi.nlm.nih.gov/pubmed/16319960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400582
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