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Reevaluation of the role of DNA polymerase θ in somatic hypermutation of immunoglobulin genes

DNA polymerase θ has been implicated in the process of somatic hypermutation in immunoglobulin variable genes based on several reports of alterations in the frequency and spectra of mutations from Polq(−/−) mice. However, these studies have contrasting results on mutation frequencies and the types o...

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Detalles Bibliográficos
Main Authors: Martomo, Stella A., Saribasak, Huseyin, Yokoi, Masayuki, Hanaoka, Fumio, Gearhart, Patricia J.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2561943/
https://ncbi.nlm.nih.gov/pubmed/18485835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2008.04.002
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