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Does DNA repair occur during somatic hypermutation?
Activation-induced deaminase (AID) initiates a flood of DNA damage in the immunoglobulin loci, leading to abasic sites, single-strand breaks and mismatches. It is compelling that some proteins in the canonical base excision and mismatch repair pathways have been hijacked to increase mutagenesis duri...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3422422/ https://ncbi.nlm.nih.gov/pubmed/22728014 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.smim.2012.05.002 |
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