Loading...

Does DNA repair occur during somatic hypermutation?

Activation-induced deaminase (AID) initiates a flood of DNA damage in the immunoglobulin loci, leading to abasic sites, single-strand breaks and mismatches. It is compelling that some proteins in the canonical base excision and mismatch repair pathways have been hijacked to increase mutagenesis duri...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Saribasak, Huseyin, Gearhart, Patricia J.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422422/
https://ncbi.nlm.nih.gov/pubmed/22728014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.smim.2012.05.002
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!