DNA polymerase ι functions in the generation of tandem mutations during somatic hypermutation of antibody genes

DNA polymerase ι (Pol ι) is an attractive candidate for somatic hypermutation in antibody genes because of its low fidelity. To identify a role for Pol ι, we analyzed mutations in two strains of mice with deficiencies in the enzyme: 129 mice with negligible expression of truncated Pol ι, and knock-i...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Maul, Robert W., MacCarthy, Thomas, Frank, Ekaterina G., Donigan, Katherine A., McLenigan, Mary P., Yang, William, Saribasak, Huseyin, Huston, Donald E., Lange, Sabine S., Woodgate, Roger, Gearhart, Patricia J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4995076/
https://ncbi.nlm.nih.gov/pubmed/27455952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151227
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