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DNA repair in antibody somatic hypermutation
Somatic hypermutation (SHM) underlies the generation of a diverse repertoire of high-affinity antibodies. It is effected by a two-step process: (i) DNA lesions initiated by activation-induced cytidine deaminase (AID), and (ii) lesion repair by the combined intervention of DNA replication and repair...
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| Publicat a: | Trends Immunol |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2006
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4623574/ https://ncbi.nlm.nih.gov/pubmed/16737852 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.it.2006.05.001 |
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