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Regulation of aicda expression and AID activity: Relevance to somatic hypermutation and class switch DNA recombination

Expression and activity of activation-induced cytidine deaminase (AID) encoded by the aicda gene are essential for immunoglobulin (Ig) gene somatic hypermutation (SHM) and class switch DNA recombination (CSR). SHM and CSR unfold in general in germinal centers and are central to the maturation of eff...

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Autors principals: Xu, Zhenming, Pone, Egest J., Al-Qahtani, Ahmed, Park, Seok-Rae, Zan, Hong, Casali, Paolo
Format: Artigo
Idioma:Inglês
Publicat: 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2994649/
https://ncbi.nlm.nih.gov/pubmed/18197815
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