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DNA Lesions and Repair in Immunoglobulin Class Switch Recombination and Somatic Hypermutation

Immunoglobulin (Ig) gene somatic hypermutation (SHM) and class switch DNA recombination (CSR) are critical for the maturation of the antibody response. These processes endow antibodies with increased antigen-binding affinity and acquisition of new biological effector functions, thereby underlying th...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Ann N Y Acad Sci
Prif Awduron: XU, ZHENMING, FULOP, ZSOLT, ZHONG, YUAN, EVINGER, ALBERT J., ZAN, HONG, CASALI, PAOLO
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2005
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621013/
https://ncbi.nlm.nih.gov/pubmed/16014529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1196/annals.1313.119
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