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DNA Lesions and Repair in Immunoglobulin Class Switch Recombination and Somatic Hypermutation
Immunoglobulin (Ig) gene somatic hypermutation (SHM) and class switch DNA recombination (CSR) are critical for the maturation of the antibody response. These processes endow antibodies with increased antigen-binding affinity and acquisition of new biological effector functions, thereby underlying th...
Enregistré dans:
| Publié dans: | Ann N Y Acad Sci |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2005
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4621013/ https://ncbi.nlm.nih.gov/pubmed/16014529 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1196/annals.1313.119 |
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