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Immunoglobulin class switch DNA recombination: induction, targeting and beyond
Class switch DNA recombination (CSR) of the immunoglobulin heavy chain (IgH) locus is central to the maturation of the antibody response and critically requires the AID cytidine deaminase. CSR entails changes of the chromatin state and transcriptional activation of the IgH locus upstream and downstr...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3545482/ https://ncbi.nlm.nih.gov/pubmed/22728528 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nri3216 |
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