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Endonuclease G plays a role in immunoglobulin class switch DNA recombination by introducing double-strand breaks in switch regions
Immunoglobulin (Ig) class switch DNA recombination (CSR) is the crucial mechanism diversifying the biological effector functions of antibodies. Generation of double-strand DNA breaks (DSBs), particularly staggered DSBs, in switch (S) regions of the upstream and downstream C(H) genes involved in the...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3412130/ https://ncbi.nlm.nih.gov/pubmed/21111482 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2010.10.023 |
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