Endonuclease G plays a role in immunoglobulin class switch DNA recombination by introducing double-strand breaks in switch regions

Immunoglobulin (Ig) class switch DNA recombination (CSR) is the crucial mechanism diversifying the biological effector functions of antibodies. Generation of double-strand DNA breaks (DSBs), particularly staggered DSBs, in switch (S) regions of the upstream and downstream C(H) genes involved in the...

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Main Authors: Zan, Hong, Zhang, Jinsong, Al-Qahtani, Ahmed, Pone, Egest J., White, Clayton A., Lee, Derrik, Yel, Leman, Mai, Thach, Casali, Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412130/
https://ncbi.nlm.nih.gov/pubmed/21111482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2010.10.023
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