Rev1 Recruits Ung to Switch Regions and Enhances dU Glycosylation for Immunoglobulin Class Switch DNA Recombination

By diversifying the biological effector functions of antibodies, class switch DNA recombination (CSR) plays a critical role in the maturation of the immune response. It is initiated by AID-mediated dC deamination, yielding dUs, and dU glycosylation by Ung in antibody switch (S) region DNA. Here we s...

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Hlavní autoři: Zan, Hong, White, Clayton A., Thomas, Lisa M., Mai, Thach, Li, Guideng, Xu, Zhenming, Zhang, Jinsong, Casali, Paolo
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3518390/
https://ncbi.nlm.nih.gov/pubmed/23140944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2012.09.029
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