Estrogen Receptors Bind to and Activate the HOXC4/HoxC4 Promoter to Potentiate HoxC4-mediated Activation-induced Cytosine Deaminase Induction, Immunoglobulin Class Switch DNA Recombination, and Somatic Hypermutation

Estrogen enhances antibody and autoantibody responses through yet to be defined mechanisms. It has been suggested that estrogen up-regulates the expression of activation-induced cytosine deaminase (AID), which is critical for antibody class switch DNA recombination (CSR) and somatic hypermutation (S...

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Detalhes bibliográficos
Main Authors: Mai, Thach, Zan, Hong, Zhang, Jinsong, Hawkins, J. Seth, Xu, Zhenming, Casali, Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988384/
https://ncbi.nlm.nih.gov/pubmed/20855884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.169086
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