AID dysregulation in lupus-prone MRL/Fas(lpr/lpr) mice increases class switch DNA recombination and promotes interchromosomal c-Myc/IgH loci translocations: modulation by HoxC4

Immunoglobulin (Ig) gene somatic hypermutation (SHM) and class switch DNA recombination (CSR) play important roles in the generation of autoantibodies in systemic lupus erythematosus. Systemic lupus is characterized by the production of an array of pathogenic high-affinity mutated and class-switched...

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Autores principales: WHITE, CLAYTON A., HAWKINS, J. SETH, PONE, EGEST J., YU, ELLIOT S., AL-QAHTANI, AHMED, MAI, THACH, ZAN, HONG, CASALI, PAOLO
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3762595/
https://ncbi.nlm.nih.gov/pubmed/21585311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/08916934.2011.577128
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