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Reevaluation of the role of DNA polymerase θ in somatic hypermutation of immunoglobulin genes
DNA polymerase θ has been implicated in the process of somatic hypermutation in immunoglobulin variable genes based on several reports of alterations in the frequency and spectra of mutations from Polq(−/−) mice. However, these studies have contrasting results on mutation frequencies and the types o...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2008
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2561943/ https://ncbi.nlm.nih.gov/pubmed/18485835 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2008.04.002 |
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