129-derived Strains of Mice Are Deficient in DNA Polymerase ι and Have Normal Immunoglobulin Hypermutation

Recent studies suggest that DNA polymerase η (polη) and DNA polymerase ι (polι) are involved in somatic hypermutation of immunoglobulin variable genes. To test the role of polι in generating mutations in an animal model, we first characterized the biochemical properties of murine polι. Like its huma...

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Hauptverfasser: McDonald, John P., Frank, Ekaterina G., Plosky, Brian S., Rogozin, Igor B., Masutani, Chikahide, Hanaoka, Fumio, Woodgate, Roger, Gearhart, Patricia J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2003
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194173/
https://ncbi.nlm.nih.gov/pubmed/12925679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20030767
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