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Misinsertion and bypass of thymine–thymine dimers by human DNA polymerase ι
Human DNA polymerase ι (polι) is a recently discovered enzyme that exhibits extremely low fidelity on undamaged DNA templates. Here, we show that polι is able to facilitate limited translesion replication of a thymine–thymine cyclobutane pyrimidine dimer (CPD). More importantly, however, the bypass...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2000
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC302107/ https://ncbi.nlm.nih.gov/pubmed/11013228 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.19.5259 |
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