Misinsertion and bypass of thymine–thymine dimers by human DNA polymerase ι

Human DNA polymerase ι (polι) is a recently discovered enzyme that exhibits extremely low fidelity on undamaged DNA templates. Here, we show that polι is able to facilitate limited translesion replication of a thymine–thymine cyclobutane pyrimidine dimer (CPD). More importantly, however, the bypass...

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Pubblicato in:	EMBO J
Autori principali:	Tissier, Agnès, Frank, Ekaterina G., McDonald, John P., Iwai, Shigenori, Hanaoka, Fumio, Woodgate, Roger
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 2000
Soggetti:	Articles
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC302107/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11013228/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.19.5259
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