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A Role for Msh6 But Not Msh3 in Somatic Hypermutation and Class Switch Recombination
Somatic hypermutation is initiated by activation-induced cytidine deaminase (AID), and occurs in several kilobases of DNA around rearranged immunoglobulin variable (V) genes and switch (S) sites before constant genes. AID deaminates cytosine to uracil, which can produce mutations of C:G nucleotide p...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2213309/ https://ncbi.nlm.nih.gov/pubmed/15238605 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20040691 |
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