Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation

Activation-induced cytidine deaminase (AID) is shown to be essential and sufficient to induce two genetic alterations in the Ig loci: class switch recombination (CSR) and somatic hypermutation (SHM). However, it is still unknown how a single-molecule AID differentially regulates CSR and SHM. Here we...

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Detalhes bibliográficos
Main Authors: Okazaki, Il-mi, Okawa, Katsuya, Kobayashi, Maki, Yoshikawa, Kiyotsugu, Kawamoto, Shimpei, Nagaoka, Hitoshi, Shinkura, Reiko, Kitawaki, Yoko, Taniguchi, Hisaaki, Natsume, Tohru, Iemura, Shun-Ichiro, Honjo, Tasuku
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093487/
https://ncbi.nlm.nih.gov/pubmed/21518874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1104423108
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