Activation-induced Deaminase (AID)-directed Hypermutation in the Immunoglobulin Sμ Region: Implication of AID Involvement in a Common Step of Class Switch Recombination and Somatic Hypermutation

Somatic hypermutation (SHM) and class switch recombination (CSR) cause distinct genetic alterations at different regions of immunoglobulin genes in B lymphocytes: point mutations in variable regions and large deletions in S regions, respectively. Yet both depend on activation-induced deaminase (AID)...

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Detalhes bibliográficos
Main Authors: Nagaoka, Hitoshi, Muramatsu, Masamichi, Yamamura, Namiko, Kinoshita, Kazuo, Honjo, Tasuku
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2002
Assuntos:
Brief Definitive Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193625/
https://ncbi.nlm.nih.gov/pubmed/11854365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20012144
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