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Dissociation of in vitro DNA deamination activity and physiological functions of AID mutants
Activation-induced cytidine deaminase (AID) is essential for the DNA cleavage that initiates both somatic hypermutation (SHM) and class switch recombination (CSR) of the Ig gene. Two alternative mechanisms of DNA cleavage by AID have been proposed: RNA editing and DNA deamination. In support of the...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2572969/ https://ncbi.nlm.nih.gov/pubmed/18832469 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806641105 |
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