The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination

Activation-induced cytidine deaminase (AID) is an essential factor for the class switch recombination (CSR) and somatic hypermutation (SHM) of Ig genes. CSR and SHM are initiated by AID-induced DNA breaks in the S and V regions, respectively. Because truncation or frame-shift mutations at the carbox...

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Detalhes bibliográficos
Main Authors: Doi, Tomomitsu, Kato, Lucia, Ito, Satomi, Shinkura, Reiko, Wei, Min, Nagaoka, Hitoshi, Wang, Jishu, Honjo, Tasuku
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650339/
https://ncbi.nlm.nih.gov/pubmed/19202055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0813253106
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