De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination

Activation-induced cytidine deaminase (AID) is required for class-switch recombination (CSR), somatic hypermutation, and gene conversion of Ig genes. Although AID has sequence similarity to an RNA-editing enzyme Apobec-1, how AID functions in CSR and somatic hypermutation is unknown. Because involve...

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Hlavní autoři: Doi, Tomomitsu, Kinoshita, Kazuo, Ikegawa, Masaya, Muramatsu, Masamichi, Honjo, Tasuku
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 2003
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC151392/
https://ncbi.nlm.nih.gov/pubmed/12591955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0437710100
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