C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion

Activation-induced cytidine deaminase (AID) introduces single-strand breaks (SSBs) to initiate class switch recombination (CSR), gene conversion (GC), and somatic hypermutation (SHM). CSR is mediated by double-strand breaks (DSBs) at donor and acceptor switch (S) regions, followed by pairing of DSB...

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Detalhes bibliográficos
Main Authors: Sabouri, Somayeh, Kobayashi, Maki, Begum, Nasim A., Xu, Jianliang, Hirota, Kouji, Honjo, Tasuku
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3926049/
https://ncbi.nlm.nih.gov/pubmed/24469810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1324057111
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