C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion

Activation-induced cytidine deaminase (AID) introduces single-strand breaks (SSBs) to initiate class switch recombination (CSR), gene conversion (GC), and somatic hypermutation (SHM). CSR is mediated by double-strand breaks (DSBs) at donor and acceptor switch (S) regions, followed by pairing of DSB...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Sabouri, Somayeh, Kobayashi, Maki, Begum, Nasim A., Xu, Jianliang, Hirota, Kouji, Honjo, Tasuku
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3926049/
https://ncbi.nlm.nih.gov/pubmed/24469810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1324057111
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares