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RNA-binding motifs of hnRNP K are critical for induction of antibody diversification by activation-induced cytidine deaminase
Activation-induced cytidine deaminase (AID) is the key enzyme for class switch recombination (CSR) and somatic hypermutation (SHM) to generate antibody memory. Previously, heterogeneous nuclear ribonucleoprotein K (hnRNP K) was shown to be required for AID-dependent DNA breaks. Here, we defined the...
Tallennettuna:
| Julkaisussa: | Proc Natl Acad Sci U S A |
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| Päätekijät: | , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
National Academy of Sciences
2020
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7261133/ https://ncbi.nlm.nih.gov/pubmed/32385154 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1921115117 |
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