AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination

To initiate class switch recombination (CSR) activation-induced cytidine deaminase (AID) induces staggered nick cleavage in the S region, which lies 5′ to each Ig constant region gene and is rich in palindromic sequences. Topoisomerase 1 (Top1) controls the supercoiling of DNA by nicking, rotating,...

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Detalles Bibliográficos
Main Authors: Kobayashi, Maki, Aida, Masatoshi, Nagaoka, Hitoshi, Begum, Nasim A., Kitawaki, Yoko, Nakata, Mikiyo, Stanlie, Andre, Doi, Tomomitsu, Kato, Lucia, Okazaki, Il-mi, Shinkura, Reiko, Muramatsu, Masamichi, Kinoshita, Kazuo, Honjo, Tasuku
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2799691/
https://ncbi.nlm.nih.gov/pubmed/20018730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911879106
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