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Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination

The primary antibody repertoire is generated by mechanisms involving the assembly of the exons that encode the antigen-binding variable regions of immunoglobulin heavy (IgH) and light (IgL) chains during the early development of B lymphocytes. After antigen-dependent activation, mature B lymphocytes...

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Detalhes bibliográficos
Publicado no:Microbiol Spectr
Main Authors: HWANG, JOYCE K., ALT, FREDERICK W., YEAP, LENG-SIEW
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4481323/
https://ncbi.nlm.nih.gov/pubmed/26104555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/microbiolspec.MDNA3-0037-2014
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