Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice

Activation-induced cytidine deaminase (AID) is a single-stranded (ss) DNA-specific cytidine deaminase that initiates Ig heavy chain (IgH) class switch recombination (CSR) and Ig somatic hypermutation (SHM) by deaminating cytidines within, respectively, IgH switch (S) regions and Ig variable region (...

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Main Authors: Cheng, Hwei-Ling, Vuong, Bao Q., Basu, Uttiya, Franklin, Andrew, Schwer, Bjoern, Astarita, Jillian, Phan, Ryan T., Datta, Abhishek, Manis, John, Alt, Frederick W., Chaudhuri, Jayanta
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650332/
https://ncbi.nlm.nih.gov/pubmed/19196992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812304106
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