Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice

Activation-induced cytidine deaminase (AID) is a single-stranded (ss) DNA-specific cytidine deaminase that initiates Ig heavy chain (IgH) class switch recombination (CSR) and Ig somatic hypermutation (SHM) by deaminating cytidines within, respectively, IgH switch (S) regions and Ig variable region (...

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Detalhes bibliográficos
Main Authors: Cheng, Hwei-Ling, Vuong, Bao Q., Basu, Uttiya, Franklin, Andrew, Schwer, Bjoern, Astarita, Jillian, Phan, Ryan T., Datta, Abhishek, Manis, John, Alt, Frederick W., Chaudhuri, Jayanta
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650332/
https://ncbi.nlm.nih.gov/pubmed/19196992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812304106
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