Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice

Activation-induced cytidine deaminase (AID) is a single-stranded (ss) DNA-specific cytidine deaminase that initiates Ig heavy chain (IgH) class switch recombination (CSR) and Ig somatic hypermutation (SHM) by deaminating cytidines within, respectively, IgH switch (S) regions and Ig variable region (...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Cheng, Hwei-Ling, Vuong, Bao Q., Basu, Uttiya, Franklin, Andrew, Schwer, Bjoern, Astarita, Jillian, Phan, Ryan T., Datta, Abhishek, Manis, John, Alt, Frederick W., Chaudhuri, Jayanta
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2009
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650332/
https://ncbi.nlm.nih.gov/pubmed/19196992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812304106
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