Class Switch Recombination and Somatic Hypermutation of Virus-Neutralizing Antibodies Are Not Essential for Control of Friend Retrovirus Infection

Toll-like receptor 7 and Myd88 are required for antiretroviral antibody and germinal center responses, but whether somatic hypermutation and class-switch recombination are required for antiretroviral immunity has not been examined. Mice deficient in activation-induced cytidine deaminase (AID) resist...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Kato, Maiko, Tsuji-Kawahara, Sachiyo, Kawasaki, Yuri, Kinoshita, Saori, Chikaishi, Tomomi, Takamura, Shiki, Fujisawa, Makoto, Kawada, Akira, Miyazawa, Masaaki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4300674/
https://ncbi.nlm.nih.gov/pubmed/25378499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02293-14
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