Infection of Adult Thymus with Murine Retrovirus Induces Virus-Specific Central Tolerance That Prevents Functional Memory CD8(+) T Cell Differentiation

In chronic viral infections, persistent antigen presentation causes progressive exhaustion of virus-specific CD8(+) T cells. It has become clear, however, that virus-specific naïve CD8(+) T cells newly generated from the thymus can be primed with persisting antigens. In the setting of low antigen de...

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Main Authors: Takamura, Shiki, Kajiwara, Eiji, Tsuji-Kawahara, Sachiyo, Masumoto, Tomoko, Fujisawa, Makoto, Kato, Maiko, Chikaishi, Tomomi, Kawasaki, Yuri, Kinoshita, Saori, Itoi, Manami, Sakaguchi, Nobuo, Miyazawa, Masaaki
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3961338/
https://ncbi.nlm.nih.gov/pubmed/24651250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003937
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