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Infection of Adult Thymus with Murine Retrovirus Induces Virus-Specific Central Tolerance That Prevents Functional Memory CD8(+) T Cell Differentiation
In chronic viral infections, persistent antigen presentation causes progressive exhaustion of virus-specific CD8(+) T cells. It has become clear, however, that virus-specific naïve CD8(+) T cells newly generated from the thymus can be primed with persisting antigens. In the setting of low antigen de...
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| Autori principali: | , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3961338/ https://ncbi.nlm.nih.gov/pubmed/24651250 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003937 |
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