Msh2 ATPase Activity Is Essential for Somatic Hypermutation at A-T Basepairs and for Efficient Class Switch Recombination

Somatic hypermutation (SHM) and class switch recombination (CSR) are initiated by activation-induced cytidine deaminase–mediated cytidine deamination of immunoglobulin genes. MutS homologue (Msh) 2(−/−) mice have reduced A-T mutations and CSR. This suggests that Msh2 may play a role in repairing act...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Martin, Alberto, Li, Ziqiang, Lin, Diana P., Bardwell, Philip D., Iglesias-Ussel, Maria D., Edelmann, Winfried, Scharff, Matthew D.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Rockefeller University Press 2003
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194233/
https://ncbi.nlm.nih.gov/pubmed/14568978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20030880
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