Msh2 ATPase Activity Is Essential for Somatic Hypermutation at A-T Basepairs and for Efficient Class Switch Recombination

Somatic hypermutation (SHM) and class switch recombination (CSR) are initiated by activation-induced cytidine deaminase–mediated cytidine deamination of immunoglobulin genes. MutS homologue (Msh) 2(−/−) mice have reduced A-T mutations and CSR. This suggests that Msh2 may play a role in repairing act...

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Detalhes bibliográficos
Main Authors: Martin, Alberto, Li, Ziqiang, Lin, Diana P., Bardwell, Philip D., Iglesias-Ussel, Maria D., Edelmann, Winfried, Scharff, Matthew D.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194233/
https://ncbi.nlm.nih.gov/pubmed/14568978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20030880
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