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Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation
After encounter with antigen, the antibody repertoire is shaped by somatic hypermutation (SHM), which leads to an increase in the affinity of antibodies for the antigen, and class-switch recombination (CSR), which results in a change in the effector function of antibodies. Both SHM and CSR are initi...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
The Rockefeller University Press
2007
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2118410/ https://ncbi.nlm.nih.gov/pubmed/17227912 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20062032 |
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