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Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation

After encounter with antigen, the antibody repertoire is shaped by somatic hypermutation (SHM), which leads to an increase in the affinity of antibodies for the antigen, and class-switch recombination (CSR), which results in a change in the effector function of antibodies. Both SHM and CSR are initi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Ronai, Diana, Iglesias-Ussel, Maria D., Fan, Manxia, Li, Ziqiang, Martin, Alberto, Scharff, Matthew D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118410/
https://ncbi.nlm.nih.gov/pubmed/17227912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20062032
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