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Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation

After encounter with antigen, the antibody repertoire is shaped by somatic hypermutation (SHM), which leads to an increase in the affinity of antibodies for the antigen, and class-switch recombination (CSR), which results in a change in the effector function of antibodies. Both SHM and CSR are initi...

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Detalhes bibliográficos
Main Authors: Ronai, Diana, Iglesias-Ussel, Maria D., Fan, Manxia, Li, Ziqiang, Martin, Alberto, Scharff, Matthew D.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118410/
https://ncbi.nlm.nih.gov/pubmed/17227912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20062032
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