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Complex regulation of somatic hypermutation by cis-acting sequences in the endogenous IgH gene in hybridoma cells
To create high-affinity antibodies, B cells target a high rate of somatic hypermutation (SHM) to the Ig variable-region genes that encode the antigen-binding site. This mutational process requires transcription and is triggered by activation-induced cytidine deaminase (AID), which converts deoxycyti...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2005
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1188009/ https://ncbi.nlm.nih.gov/pubmed/16087866 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0505449102 |
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