Complex regulation of somatic hypermutation by cis-acting sequences in the endogenous IgH gene in hybridoma cells

To create high-affinity antibodies, B cells target a high rate of somatic hypermutation (SHM) to the Ig variable-region genes that encode the antigen-binding site. This mutational process requires transcription and is triggered by activation-induced cytidine deaminase (AID), which converts deoxycyti...

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Bibliografiska uppgifter
Huvudupphovsmän: Ronai, Diana, Iglesias-Ussel, Maria Dolores, Fan, Manxia, Shulman, Marc J., Scharff, Matthew D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2005
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1188009/
https://ncbi.nlm.nih.gov/pubmed/16087866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0505449102
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