Loading...
Complex regulation of somatic hypermutation by cis-acting sequences in the endogenous IgH gene in hybridoma cells
To create high-affinity antibodies, B cells target a high rate of somatic hypermutation (SHM) to the Ig variable-region genes that encode the antigen-binding site. This mutational process requires transcription and is triggered by activation-induced cytidine deaminase (AID), which converts deoxycyti...
Na minha lista:
| Main Authors: | , , , , |
|---|---|
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2005
|
| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1188009/ https://ncbi.nlm.nih.gov/pubmed/16087866 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0505449102 |
| Tags: |
Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!
|