An element in the endogenous IgH locus stimulates gene targeting in hybridoma cells.

Gene targeting of the immunoglobulin (Ig) heavy chain locus is the basis of improved methods of investigating gene expression and of antibody engineering. The VH-Cmu intron is a convenient region for mediating homologous recombination events which result in production of Ig bearing an altered heavy...

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Veröffentlicht in:	Nucleic Acids Res
Hauptverfasser:	Buzina, A, Shulman, M J
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Oxford University Press 1996
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC145805/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8628687/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/24.8.1525
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