Production of Antigen-Specific Human Monoclonal Antibodies: Comparison of Mice Carrying IgH/κ or IgH/κ/λ Transloci
Here we compare human monoclonal antibody (MAb) production from mouse strains that carry disruptions of their endogenous mouse IgH/Igκ loci and harbor human IgM + Igκ (BABκ) or human IgM + Igκ + Igλ transloci (BABκ,λ). We found that whereas both strains proved effective for the isolation of antigen-...
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| Principais autores: | , , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Taylor & Francis Group
2002-09-01
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| Serier: | BioTechniques |
| Online adgang: | https://www.future-science.com/doi/10.2144/02333dd04 |
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