Exuberant long noncoding RNA expression may sculpt Igh locus topology

Diverse Igh repertoires require successful V(D)J recombination allowing B cell receptor expression and Ig secretion for humoral immune responses. Igh locus contraction has been implicated in generating spatial proximity between distal VH segments and the recombination center via cohesin mediated loo...

Popoln opis

Bibliografske podrobnosti

Principais autores:	Ellen B. Drake, Sarah Naiyer, Xinyan Qu, Khalid Bhat, Hammad Farooq, Mark Maienschein-Cline, Jie Liang, Amy L. Kenter
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2025-11-01
Serija:	Frontiers in Immunology
Teme:	progenitor B cells V(D)J recombination IgH locus chromatin folding long non-coding RNA
Online dostop:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1678105/full
Oznake:	Označite Brez oznak, prvi označite!