An element in the endogenous IgH locus stimulates gene targeting in hybridoma cells.
Gene targeting of the immunoglobulin (Ig) heavy chain locus is the basis of improved methods of investigating gene expression and of antibody engineering. The VH-Cmu intron is a convenient region for mediating homologous recombination events which result in production of Ig bearing an altered heavy...
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| Udgivet i: | Nucleic Acids Res |
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| Principais autores: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
1996
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC145805/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8628687/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/24.8.1525 |
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