The IgH 3′ regulatory region controls somatic hypermutation in germinal center B cells

Interactions with cognate antigens recruit activated B cells into germinal centers where they undergo somatic hypermutation (SHM) in V(D)J exons for the generation of high-affinity antibodies. The contribution of IgH transcriptional enhancers in SHM is unclear. The E(μ) enhancer upstream of C(μ) has...

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Autors principals: Rouaud, Pauline, Vincent-Fabert, Christelle, Saintamand, Alexis, Fiancette, Rémi, Marquet, Marie, Robert, Isabelle, Reina-San-Martin, Bernardo, Pinaud, Eric, Cogné, Michel, Denizot, Yves
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2013
Matèries:
Brief Definitive Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3727322/
https://ncbi.nlm.nih.gov/pubmed/23825188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20130072
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