Enhancers Located in Heavy Chain Regulatory Region (hs3a, hs1,2, hs3b, and hs4) Are Dispensable for Diversity of VDJ Recombination

V(D)J recombination occurs during the antigen-independent early steps of B-cell ontogeny. Multiple IgH cis-regulatory elements control B-cell ontogeny. IGCR1 (intergenic control region 1), the DQ52 promoter/enhancer, and the intronic Emu enhancer, all three located upstream of Cmu, have important ro...

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Detalhes bibliográficos
Main Authors: Rouaud, Pauline, Vincent-Fabert, Christelle, Fiancette, Remi, Cogné, Michel, Pinaud, Eric, Denizot, Yves
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318744/
https://ncbi.nlm.nih.gov/pubmed/22270371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.341024
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