The IgH 3′ regulatory region governs μ chain transcription in mature B lymphocytes and the B cell fate

We report that the IgH 3′ regulatory region (3′RR) has no role on μ chain transcription and pre-BCR expression in B cell progenitors. In contrast, analysis of heterozygous IgH a(Δ3′RR)/b(wt) mice indicated that the 3′RR controls μ chain transcripts in mature splenocytes and impacts membrane IgM dens...

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Bibliografiska uppgifter
I publikationen:Oncotarget
Huvudupphovsmän: Saintamand, Alexis, Rouaud, Pauline, Garot, Armand, Saad, Faten, Carrion, Claire, Oblet, Christelle, Cogné, Michel, Pinaud, Eric, Denizot, Yves
Materialtyp: Artigo
Språk:Inglês
Publicerad: Impact Journals LLC 2015
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467119/
https://ncbi.nlm.nih.gov/pubmed/25742787
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