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Elucidation of the enigmatic IgD class-switch recombination via germline deletion of the IgH 3′ regulatory region
Classical class-switch recombination (cCSR) substitutes the C(μ) gene with C(γ), C(ε), or C(α), thereby generating IgG, IgE, or IgA classes, respectively. This activation-induced deaminase (AID)–driven process is controlled by the IgH 3′ regulatory region (3′RR). Regulation of rare IgD CSR events ha...
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| Hoofdauteurs: | , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
The Rockefeller University Press
2014
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4010897/ https://ncbi.nlm.nih.gov/pubmed/24752300 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20131385 |
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