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Msh2 ATPase Activity Is Essential for Somatic Hypermutation at A-T Basepairs and for Efficient Class Switch Recombination
Somatic hypermutation (SHM) and class switch recombination (CSR) are initiated by activation-induced cytidine deaminase–mediated cytidine deamination of immunoglobulin genes. MutS homologue (Msh) 2(−/−) mice have reduced A-T mutations and CSR. This suggests that Msh2 may play a role in repairing act...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The Rockefeller University Press
2003
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2194233/ https://ncbi.nlm.nih.gov/pubmed/14568978 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20030880 |
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