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The translesion DNA polymerase θ plays a dominant role in immunoglobulin gene somatic hypermutation
Immunoglobulin (Ig) somatic hypermutation (SHM) critically underlies the generation of high-affinity antibodies. Mutations can be introduced by error-prone polymerases such as polymerase ζ (Rev3), a mispair extender, and polymerase η, a mispair inserter with a preference for dA/dT, while repairing D...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1276717/ https://ncbi.nlm.nih.gov/pubmed/16222339 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600833 |
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