The Translesion DNA Polymerase ζ Plays a Major Role in Ig and bcl-6 Somatic Hypermutation

Ig somatic mutations would be introduced by a polymerase (pol) while repairing DNA outside main DNA replication. We show that human B cells constitutively express the translesion pol ζ, which effectively extends DNA past mismatched bases (mispair extender), and pol η, which bypasses DNA lesions in a...

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Bibliografiska uppgifter
I publikationen:Immunity
Huvudupphovsmän: Zan, Hong, Komori, Atsumasa, Li, Zongdong, Cerutti, Andrea, Schaffer, András, Flajnik, Martin F., Diaz, Marilyn, Casali, Paolo
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2001
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4632985/
https://ncbi.nlm.nih.gov/pubmed/11371365
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