AID-Dependent Generation of Resected Double-Strand DNA Breaks and Recruitment of Rad52/Rad51 in Somatic Hypermutation

Somatic hypermutation (SHM) of immunoglobulin (Ig) genes appears to involve the generation of double-strand DNA breaks (DSBs) and their error-prone repair. Here we show that DSBs occur at a high frequency in unrearranged (germline) Ig variable (V) genes, BCL6 and c-MYC. These DSBs are blunt, target...

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Bibliografiske detaljer
Udgivet i:Immunity
Main Authors: Zan, Hong, Wu, Xiaoping, Komori, Atsumasa, Holloman, William K., Casali, Paolo
Format: Artigo
Sprog:Inglês
Udgivet: 2003
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4625537/
https://ncbi.nlm.nih.gov/pubmed/12818155
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