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AID-Dependent Generation of Resected Double-Strand DNA Breaks and Recruitment of Rad52/Rad51 in Somatic Hypermutation
Somatic hypermutation (SHM) of immunoglobulin (Ig) genes appears to involve the generation of double-strand DNA breaks (DSBs) and their error-prone repair. Here we show that DSBs occur at a high frequency in unrearranged (germline) Ig variable (V) genes, BCL6 and c-MYC. These DSBs are blunt, target...
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| Yayımlandı: | Immunity |
|---|---|
| Asıl Yazarlar: | , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2003
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4625537/ https://ncbi.nlm.nih.gov/pubmed/12818155 |
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