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Induction of Ig Somatic Hypermutation and Class Switching in a Human Monoclonal IgM(+) IgD(+) B Cell Line In Vitro: Definition of the Requirements and Modalities of Hypermutation()
Partly because of the lack of a suitable in vitro model, the trigger(s) and the mechanism(s) of somatic hypermutation in Ig genes are largely unknown. We have analyzed the hypermutation potential of human CL-01 lymphocytes, our monoclonal model of germinal center B cell differentiation. These cells...
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| Publicado no: | J Immunol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4623562/ https://ncbi.nlm.nih.gov/pubmed/10092799 |
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