Induction of Ig Somatic Hypermutation and Class Switching in a Human Monoclonal IgM(+) IgD(+) B Cell Line In Vitro: Definition of the Requirements and Modalities of Hypermutation()

Partly because of the lack of a suitable in vitro model, the trigger(s) and the mechanism(s) of somatic hypermutation in Ig genes are largely unknown. We have analyzed the hypermutation potential of human CL-01 lymphocytes, our monoclonal model of germinal center B cell differentiation. These cells...

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Bibliographic Details
Published in:J Immunol
Main Authors: Zan, Hong, Cerutti, Andrea, Dramitinos, Patricia, Schaffer, András, Li, Zongdong, Casali, Paolo
Format: Artigo
Language:Inglês
Published: 1999
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4623562/
https://ncbi.nlm.nih.gov/pubmed/10092799
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